Understanding MS Infusion Medication Options

Multiple sclerosis is a chronic disease that affects the central nervous system, which includes the brain and spinal cord. In MS, the immune system mistakenly attacks the protective covering of nerve fibers called myelin.

When myelin is damaged, nerve signals slow down or stop. This leads to various symptoms, including numbness or tingling in different parts of the body, weakness in limbs, vision problems, difficulty with coordination and balance, and fatigue. These symptoms can vary widely from person to person, and they may fluctuate or worsen over time. ​

While there is currently no cure, relief is possible with MS infusion medications that can help manage your condition.

Disease-Modifying MS Infusion Medications

Disease-modifying infusion medications aim to reduce the frequency and severity of relapses while slowing disease progression. They also manage specific symptoms, ultimately improving the overall quality of life.

What infusions are used for MS, and how do they work?

Ocrevus® (ocrelizumab)

Ocrevus is a treatment for both relapsing MS and primary progressive MS. Administered every six months, this medication works by targeting a type of immune cell called B cells, which are known to attack the protective covering around nerves. By lowering the number of these cells, Ocrevus helps reduce flare-ups and slows the disease’s progress. 

Tysabri® (natalizumab)

Tysabri is a monthly infusion used to treat relapsing forms of MS. It works by stopping harmful immune cells from entering your brain and spinal cord, where they can cause damage. This helps lower the chances of flare-ups and prevents new damage from forming. Due to a rare but serious brain infection risk, your doctor will carefully monitor your health while you’re on Tysabri.

Lemtrada® (alemtuzumab)

Lemtrada is a powerful MS infusion medication used for people with relapsing MS. It works by removing certain immune cells that attack your nerves. After the treatment, your immune system builds itself back up, hopefully without as many of the cells that cause damage. Lemtrada is given through an IV once a year for two years, with regular blood and health checks.

Briumvi® (ublituximab-xiiy)

Briumvi is a newer treatment for relapsing MS. It targets and lowers the number of B cells in your immune system. Briumvi helps reduce relapses, slow down the disease, and prevent new damage in the brain. It starts with a few doses close together, followed by one infusion every six months.

Supportive Infusion Treatments for MS

Depending on your specific condition, your doctor may recommend a non-disease-modifying infusion given for MS or a supportive treatment that can help you through attacks or relapses.

Intravenous Immunoglobulin (IVIG)

IVIG is a supportive treatment where you receive antibodies from donated blood through an IV. Doctors might use it in special situations, like during pregnancy or when other treatments haven’t worked. IVIG helps balance your immune system to reduce attacks on your nerves. Each infusion usually takes 2 to 3 hours, and you might get them every 4 to 5 weeks, depending on your doctor’s plan.

Solumedrol® (methylprednisolone sodium succinate)

Solumedrol is a steroid medicine given through an IV to help control sudden MS flare-ups. It works by reducing inflammation in your nervous system, which can quickly lessen symptoms like vision problems, numbness, or weakness. Typically, you’ll receive this treatment daily for a few days, and it can help you recover faster from an MS attack.

Rituxan® (rituximab)

Rituxan is a medication originally approved for certain blood cancers and rheumatoid arthritis but is also used off-label to treat MS. It targets and reduces specific B cells in your immune system that are involved in the attack on your nervous system. Treatment involves infusions given at intervals determined by your doctor, and it’s generally well-tolerated with few and mild side effects.

Cyclophosphamide

Cyclophosphamide is a chemotherapy drug sometimes used off-label for severe or rapidly worsening MS cases. It works by suppressing your immune system to reduce the attack on your nervous system. This treatment is typically considered when other therapies haven’t been effective. However, its use may be limited due to potential side effects and low tolerability.

How MS Infusion Treatments Work

You will typically receive your MS infusion meds in a medical setting, such as an outpatient infusion center like Healix. During the infusion, you’ll be comfortably seated as a nurse inserts a small needle into a vein in your arm or hand, connecting it to an IV line that delivers the medication directly into your bloodstream.

The infusion duration varies depending on the specific drug and dosage, ranging from 30 minutes to several hours. Throughout this period and for a short time after, your healthcare team will monitor you for any immediate reactions before you resume your normal activities.

Potential Infusion Reactions

While infusion treatments can be beneficial, they may cause reactions during or shortly after the procedure. Common reactions include itching, rash, hives, redness of the face, throat irritation or pain, fever, fatigue, and headache. These reactions are usually mild and temporary, but it’s important to inform your healthcare provider if you experience any discomfort during or after the infusion.​

Possible Side Effects of MS Infusion Medications

While MS infusion medications are often effective, they can have side effects, which may include:

• Back pain
• Swelling of the face, arms, hands, lower legs, or feet
• Blurred vision
• Body aches or pain
• Chest tightness

Some serious but rare side effects can occur:

• Swelling in the mouth or throat
• Trouble breathing
• Chest pain
• Increased risk of infections

Always discuss potential side effects with your healthcare provider before receiving an infusion. This conversation helps you understand possible risks and ensures you’re prepared to manage any reactions.

Live Better With MS Infusion Medications

Infusion treatments for MS can help you better manage your complex condition and improve your daily life. Talk to your doctor to explore how MS infusion medications can make a difference for you, then learn how to get started with Healix Infusion Care so you can take back control of your health.

This information is for educational and informational purposes only and does not constitute medical advice or professional services. It is intended as a general resource to aid in understanding diagnoses and treatment options. If you have concerns about a medical condition or are interested in a specific treatment, please consult your healthcare provider.