How Much Does Briumvi Cost?
Where treatment is administered can significantly influence overall expenses. For example, according to the AHIP, outpatient infusion centers typically cost an average of $7,000 less than hospitals, which apply additional facility fees and higher service charges.
Briumvi also offers a copay assistance program for eligible patients that can reduce yearly costs
Briumvi Prescribing Information Highlights
These prescribing information highlights do not include all the information required to ensure Briumvi is used safely and effectively. Healthcare providers should review the full Briumvi prescribing information for complete details on usage, warnings, and precautions.
Treatment Preparation
Before administering the first dose of Briumvi, conduct the following assessments:
- HBV Screening: Briumvi is contraindicated for patients with active hepatitis B
- Serum Immunoglobulins: Consult an immunologist for recommendations for patients with low Igs
- Vaccinations: Live-attenuated or live vaccines should be administered at least four weeks prior to infusion therapy; two weeks for non-live vaccines
Briumvi infusions may raise the risk of serious infections or potentially cause fetal harm. Therefore, healthcare providers should evaluate patients for active infections and check for pregnancy before each infusion.
Pre-Infusion Medications
To reduce the risk and severity of infusion-related reactions, pre-medicate with the following before each Briumvi infusion:
- Methylprednisolone (100 mg) intravenously (or an equivalent corticosteroid) approximately 30 minutes prior
- Antihistamine (e.g., diphenhydramine) orally or intravenously approximately 30 to 60 minutes prior
- Antipyretic (e.g., acetaminophen) prior to each infusion
Healthcare providers may adjust the choice and dosage of antihistamines and antipyretics based on individual patient factors and clinical judgment.
Treatment Time and Dosage
The first two intravenous infusions should be administered on day 1 and day 15, with maintenance infusions every 24 weeks:
- First infusion is 150 mg (6 mL) over 4 hours:
- 10 mL/hr for the first 30 minutes
- 20 mL/hr for the next 30 minutes
- 35 mL/hr for the next hour
- 100 mL/hr for the remaining 2 hours
- Second and subsequent infusions are 450 mg (18 mL) over 1 hour:
- 100 mL/hr for the first 30 minutes
- 400 mL/hr for the remaining 30 minutes