Therapies

Ocrevus® Infusion

Treats both relapsing and primary progressive forms of multiple sclerosis (MS).
Ocrevus infusion, Ocrevus, Healix Infusion Care
Ocrevus infusion, Ocrevus, Healix Infusion Care
Ocrevus infusion, Ocrevus, Healix Infusion Care

Ocrevus® Infusion

Ocrevus® (ocrelizumab) is the first FDA-approved medication that treats both relapsing and primary progressive forms of multiple sclerosis. By targeting specific immune cells, Ocrevus helps reduce flare-ups and slow disease progression for many people managing MS.

What Is Ocrevus Infusion Therapy?

Ocrevus infusion therapy is a monoclonal antibody treatment designed to target CD20-positive B-cells, which play a role in the immune system’s attack on the nervous system in MS. By reducing these cells, Ocrevus helps protect nerve fibers, decrease new brain or spinal cord lesions, and improve mobility in some patients. 

Ocrevus is given through an intravenous infusion, delivering it directly into the bloodstream. This prescription medication is typically administered in an outpatient treatment center like Healix Infusion Care, where healthcare providers can closely monitor patients during the infusion.

What Conditions Does Ocrevus Treat?

Ocrevus has been clinically proven to manage these specific forms of MS in adults:

  • Relapsing-Remitting MS 
  • Active Secondary Progressive MS 
  • Clinically Isolated Syndrome 
  • Primary Progressive MS 

Ocrevus is not approved for use in children

What Are the Possible Ocrevus Side Effects?

Some patients may experience an Ocrevus infusion reaction either during or up to 24 hours after the treatment, such as:

  • Itchy skin or rash
  • Coughing, wheezing, or difficulty breathing
  • Throat swelling or irritation
  • Nausea 
  • Headache
  • Tiredness
  • Dizziness
  • Rapid heartbeat
  • Flushing

Most of these reactions are minor and only require an infusion adjustment. Patients should be monitored for Ocrevus side effects for at least 1 hour post-procedure. Anaphylaxis is rare but possible.

Infection Risk

Ocrevus can increase a patient’s risk of serious infections, including respiratory and herpes infections. Patients should inform their healthcare provider promptly if they develop the following:

  • Persistent cough
  • Cold sores
  • Shingles
  • Vision changes
  • Severe headaches
  • Confusion

If an infection occurs, Ocrevus treatment may be delayed until it has fully resolved.

Rare Side Effects

Progressive multifocal leukoencephalopathy (PML) is a rare but serious brain infection that has been reported in people receiving Ocrevus. Because Ocrevus can weaken immune defenses, it may allow the virus to harm nerve cells in the brain. 

Symptoms of PML include new or worsening cognitive impairments, visual problems, and mobility symptoms. PML can lead to severe disability or become life-threatening if not addressed promptly.

Who Should Not Receive Ocrevus?

Before receiving Ocrevus, patients should tell their healthcare provider if they:

  • Have or suspect an infection
  • Have previously used, are currently using, or plan to use medicines that affect the immune system or other MS treatments
  • Have ever had hepatitis B or currently carry the virus
  • Have been diagnosed with inflammatory bowel disease or colitis in the past
  • Have recently received a vaccine, or are planning to get vaccinated in the near future
  • Are pregnant, think they might be pregnant, or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Ocrevus and Pregnancy

The effect of Ocrevus on pregnancy has not been well-studied, but most monoclonal antibodies can cross the placenta and increase the risk of infections in newborns. Furthermore, while MS symptoms often stabilize during pregnancy, there is a higher risk of postpartum relapse, especially in mothers who discontinued Ocrevus infusion therapy to protect the fetus.

Ocrevus infusion, Ocrevus, Healix Infusion Care
Ocrevus infusion, Ocrevus, Healix Infusion Care
Ocrevus infusion, Ocrevus, Healix Infusion Care
Ocrevus infusion, Ocrevus, Healix Infusion Care
Ocrevus infusion, Ocrevus, Healix Infusion Care

How Much Does Ocrevus Cost?

Ocrevus’ out-of-pocket cost can vary based on insurance coverage, location, and site of care. However, research from AHIP indicates that outpatient infusion centers often provide a more affordable option, averaging $7,000 less than hospitals, where facility fees and higher service charges drive up costs. 

Additionally, the Genentech Patient Foundation may offer assistance for patients who are uninsured or unable to afford their share of the cost.

How Is Ocrevus Administered?

Ocrevus is typically given as two initial 300 mg infusions two weeks apart, followed by a single 600 mg infusion every six months. Patients should plan for a total appointment time of about 5.5 hours for each infusion.

Pre-Infusion (30–60 Minutes)

Before starting Ocrevus, patients typically receive premedication (corticosteroid; antihistamine), which can be given by mouth or through an IV. This step helps reduce the chance of experiencing infusion-related reactions.

Infusion (2.5 hours for initial infusions; 3.5 hours for maintenance doses)

During the infusion, patients are seated in a comfortable chair while a thin needle is placed in the arm to deliver Ocrevus through an IV drip. An automatic pump carefully regulates the rate of administration. If any infusion reactions occur, the healthcare team may pause or slow the infusion to manage symptoms.

Post-Infusion (At Least 1 Hour)

Once the Ocrevus infusion is complete, patients remain under observation for at least one hour. This allows the healthcare team to watch for any side effects or issues that may arise following treatment.

Future 2-Hour Infusions

After tolerating the initial and maintenance infusions without serious reactions, if approved by their referring provider, some patients may qualify for a shorter, 2-hour infusion for future treatments. The total dose of Ocrevus remains the same but is administered more quickly.

Who Makes Ocrevus​?

Ocrevus is manufactured by Genentech, a member of the Roche Group.

Receive Specialized Ocrevus Infusion Care at Healix

Patients who are prescribed Ocrevus or another infusion-based treatment benefit from Healix Infusion Care’s specialized, patient-centered approach. Our experienced infusion team provides personalized therapy for individuals managing long-term conditions. Explore our range of infusion services, learn about the diverse conditions we treat, and discover how Healix supports every step of the treatment process

Ocrevus infusion, Ocrevus, Healix Infusion Care
Explore More Therapies