Therapies

Rituximab & Biosimilars Therapy Page

rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care
rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care
rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care

What Is Rituximab?

Rituximab & biosimilars are monoclonal antibodies that target the CD20 protein found on the surface of B leukocytes, a type of white blood cell. These medicines are administered through an IV and help eliminate targeted B cells from your body, which can be beneficial in certain autoimmune diseases and cancers.​ You can receive a rituximab infusion at an outpatient infusion clinic like Healix.

How Rituximab Works

The rituximab mechanism of action involves binding to the CD20 protein on B cells. This binding marks B leukocytes for destruction through several processes:

  • Complement-Dependent Cytotoxicity, or CDC: Activation of the complement system, a part of your immune system that clears damaged B cells
  • Antibody-Dependent Cellular Cytotoxicity, or ADCC: Activation of immune cells that recognize and destroy marked B cells
  • Apoptosis: Intentional self-destruction of damaged, unnecessary, or potentially harmful B cells

Rituximab Biosimilars

Pharmaceutical companies have developed and approved rituximab biosimilar versions as patents for the original drug have expired. Biosimilars are medications highly similar to an already approved biological product, known as the reference product, and have no clinically meaningful differences in safety, purity, and potency. FDA-approved rituximab biosimilars include:​

  • Truxima® (rituximab-abbs)​
  • Ruxience® (rituximab-pvvr)​
  • Riabni® (rituximab-arrx)​

These biosimilars provide more treatment options and may help reduce healthcare costs.

What Conditions Do Rituximab Infusions Treat?

A rituximab infusion helps treat diseases where B leukocytes cause harm by being too active, behaving abnormally, or turning cancerous. Your doctor may recommend rituximab to manage symptoms, slow disease progression, or destroy harmful cells.

You might receive rituximab or biosimilars for one of these conditions:

  • Non-Hodgkin’s Lymphoma: Cancer of the lymphatic system where abnormal B cells grow uncontrollably
  • Rheumatoid Arthritis: Autoimmune disease where B cells attack your joints and cause long-term damage
  • Chronic Lymphocytic Leukemia: Slow-growing cancer in the blood and bone marrow caused by faulty B cells
  • Microscopic Polyangiitis: Similar to GPA, causing inflammation in small blood vessels throughout the body
  • Pemphigus Vulgaris: Serious skin condition where the immune system attacks the layer between skin cells, causing painful blisters
  • Granulomatosis With Polyangiitis: Rare disease where blood vessels become inflamed and damage organs

These conditions respond to rituximab because it targets the B cells involved in causing damage. It isn’t always the first treatment, but it’s often used when other medications don’t work or when fast immune system control is needed.

rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care
rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care
rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care
rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care
rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care

What Are the Potential Side Effects of Rituximab?

Like most medications, rituximab infusions have side effects that may vary depending on your health and how your body responds to the treatment. Many are mild and fade on their own, while others are more serious and need medical attention.

Common Side Effects

  • Fever or chills
  • Headache
  • Fatigue
  • Nausea
  • Muscle or joint pain
  • Skin rash or itching

Rare but Serious Side Effects

  • Severe lung problems, including shortness of breath or inflammation
  • Heart problems, like chest pain or irregular heartbeat
  • Kidney failure
  • Severe skin reactions such as blistering or peeling
  • Bowel blockage or tears (especially in people with cancer)
  • Severe allergic reactions outside of infusion days

Infusion Reactions

Rituximab infusion reactions are the most common side effect during your first dose. These can happen within 30 minutes to a few hours after treatment starts. You may feel symptoms like a tight chest, trouble breathing, dizziness, or a rapid heartbeat. Some people also get hives or swelling in the face or throat.

Your care team usually gives you medicines before the infusion to help prevent this, and they will monitor you closely during the process.

What Are the Effects of Rituximab on the Immune System?

B leukocytes normally help fight infections. Since rituximab therapy lowers the number of B cells in your body, you may be more likely to get sick following treatment.

Some infections, like colds, might be mild. However, others can be severe, especially because your immune system may stay low for as many as six to nine months, sometimes longer. Your doctor may check your blood regularly to watch your immune cell levels and look for signs of infection.

While taking rituximab, you should take extra precautions:

  • Wash your hands often
  • Avoid contact with people who are sick
  • Stay up to date on vaccines

It’s important to note that some live vaccines may not be safe while you’re on treatment.

Let your care team know immediately if you have a fever, cough, sore throat, or any signs of infection. They may adjust your treatment or prescribe medicine to protect you.

Experience Relaxed Rituximab Infusion Therapy at Healix

At Healix Infusion Care, we take the stress out of infusion therapy by treating you in a quiet, private setting — not a crowded hospital room. You’ll also experience these benefits:

  • Flexible scheduling
  • Same skilled staff at every visit
  • Strict safety protocols
  • Advanced infusion technology
  • Fast insurance processing

Get started with Healix today for your rituximab infusion therapy for autoimmune disease or cancer.

rituximab infusion, Rituximab Infusion & Biosimilars, Healix Infusion Care
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